SelSim：一个用于模拟具有自然选择和重组的群体遗传数据的程序。

SelSim: a program to simulate population genetic data with natural selection and recombination.

作者信息

Spencer Chris C A, Coop Graham

机构信息

Department of Statistics, 1 South Parks Road, Oxford OX1 3TG, UK.

出版信息

Bioinformatics. 2004 Dec 12;20(18):3673-5. doi: 10.1093/bioinformatics/bth417. Epub 2004 Jul 22.

DOI:10.1093/bioinformatics/bth417

PMID:15271777

Abstract

UNLABELLED

SelSim is a program for Monte Carlo simulation of DNA polymorphism data for a recombining region within which a single bi-allelic site has experienced natural selection. SelSim allows simulation from either a fully stochastic model of, or deterministic approximations to, natural selection within a coalescent framework. A number of different mutation models are available for simulating surrounding neutral variation. The package enables a detailed exploration of the effects of different models and strengths of selection on patterns of diversity. This provides a tool for the statistical analysis of both empirical data and methods designed to detect natural selection.

AVAILABILITY

http://www.stats.ox.ac.uk/mathgen/software.html.

SUPPLEMENTARY INFORMATION

http://www.stats.ox.ac.uk/mathgen/software.html.

摘要

未标注

SelSim是一个用于对DNA多态性数据进行蒙特卡罗模拟的程序，该数据针对一个重组区域，其中单个双等位基因位点经历了自然选择。SelSim允许在合并框架内从自然选择的完全随机模型或确定性近似模型进行模拟。有多种不同的突变模型可用于模拟周围的中性变异。该软件包能够详细探索不同模型和选择强度对多样性模式的影响。这为实证数据以及旨在检测自然选择的方法的统计分析提供了一个工具。