促红细胞生成素作为一种新型神经保护剂。

Erythropoietin as a novel neuroprotectant.

作者信息

Genc Sermin, Koroglu Tolga F, Genc Kursad

机构信息

Department of Medical Biology and Genetics, School of Medicine, Dokuz Eylul University, Inciralti, 35340, Izmir, Turkey.

出版信息

Restor Neurol Neurosci. 2004;22(2):105-19.

PMID:15272145

Abstract

PURPOSE

To provide an overview of the current knowledge on neuroprotective properties of Erythropoietin (Epo), mechanisms by which Epo produces neuroprotection, and signaling pathways regulated by Epo in the nervous system.

METHODS

The Medline database was searched for articles on the neuroprotective properties of Epo. Experimental and clinical studies were systematically reviewed.

RESULTS

In addition to promoting the survival, proliferation, and differentiation of immature erythroid cells, Epo and the Epo receptor (EpoR) have recently been shown to exist and function in the nervous system. The Epo/EpoR system plays a critical role in neurodevelopment and neuroprotection. Epo ameliorates or prevents neuronal injury by neuroprotective, anti-apoptotic, anti-inflammatory, anti-oxidant, angiogenic, neurogenic and neurotrophic effects in cell culture and animal models of neurological diseases. The clinical effectiveness of recombinant human Epo in ischemic stroke in human patients has also been reported recently.

CONCLUSION

Recent studies suggest that Epo is a potential novel neurotherapeutic agent and further clinical studies are warranted.

摘要

目的

概述目前关于促红细胞生成素（Epo）神经保护特性、Epo产生神经保护作用的机制以及Epo在神经系统中调节的信号通路的知识。

方法

检索Medline数据库中关于Epo神经保护特性的文章。对实验和临床研究进行系统综述。

结果

除了促进未成熟红细胞的存活、增殖和分化外，Epo和Epo受体（EpoR）最近已被证明在神经系统中存在并发挥作用。Epo/EpoR系统在神经发育和神经保护中起关键作用。在神经疾病的细胞培养和动物模型中，Epo通过神经保护、抗凋亡、抗炎、抗氧化、血管生成、神经发生和神经营养作用改善或预防神经元损伤。最近也报道了重组人Epo在人类缺血性卒中患者中的临床有效性。