促红细胞生成素：一种新型神经保护细胞因子。

Erythropoietin: a novel neuroprotective cytokine.

作者信息

Bartesaghi Stefano, Marinovich Marina, Corsini Emanuela, Galli Corrado L, Viviani Barbara

机构信息

Laboratory of Toxicology and Centre of Excellence on Neurodegenerative Diseases, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy.

出版信息

Neurotoxicology. 2005 Oct;26(5):923-8. doi: 10.1016/j.neuro.2005.01.016. Epub 2005 May 31.

DOI:10.1016/j.neuro.2005.01.016

PMID:15927257

Abstract

Erythropoietin (Epo), the principal regulator of erythroids progenitor cells, greatly improves neuronal survival. A wide variety of experimental studies have shown that both Epo and the EpoR are functionally expressed in the nervous system and that this cytokine exerts a remarkable neuroprotection both in vitro against different neurotoxicants and in animal models of nervous system disorders. Aim of this review is to summarize the neuroprotective properties of Epo and to outline the molecular mechanisms involved in order to point out the signal transduction pathway which may represent the potential basis for future strategies against neuronal injury.

摘要

促红细胞生成素（Epo）是红系祖细胞的主要调节因子，能显著提高神经元的存活率。大量实验研究表明，Epo和促红细胞生成素受体（EpoR）在神经系统中均有功能性表达，并且这种细胞因子在体外对不同神经毒素以及在神经系统疾病动物模型中都发挥着显著的神经保护作用。本综述的目的是总结Epo的神经保护特性，并概述其涉及的分子机制，以指出可能代表未来抗神经元损伤策略潜在基础的信号转导途径。