一例氨氯地平中毒致死病例。

A fatal case of amlodipine poisoning.

作者信息

Johansen Sys Stybe, Genner Jørgen

机构信息

Department of Forensic Chemistry and Department of Forensic Pathology, Institute of Forensic Medicine, University of Copenhagen, Copenhagen, Denmark.

出版信息

J Clin Forensic Med. 2003 Sep;10(3):169-72. doi: 10.1016/S1353-1131(03)00043-9.

DOI:10.1016/S1353-1131(03)00043-9

PMID:15275013

Abstract

A fatal overdose of amlodipine, a calcium channel blocker, in a 50-year-old man is described. Biological samples obtained at autopsy were screened for common drugs and narcotics. The amlodipine determination was made by HPLC with diode-array detection and a post-mortem blood concentration of 2.3 mg/kg was determined. The only other drug detected was a blood alcohol concentration of 0.008%. The presence of amlodipine was confirmed in other tissues and in the stomach content. The overdose is assumed to be an accumulation of amlodipine due to the long half-life of this drug.

摘要

本文描述了一名50岁男性因过量服用钙通道阻滞剂氨氯地平致死的案例。对尸检时采集的生物样本进行了常见药物和麻醉品筛查。采用高效液相色谱-二极管阵列检测法测定氨氯地平，测定出死后血液浓度为2.3mg/kg。检测到的唯一其他药物是血液酒精浓度为0.008%。在其他组织和胃内容物中也证实了氨氯地平的存在。据推测，此次过量用药是由于该药物半衰期长导致氨氯地平蓄积所致。