Wilffert B, Boskma R J, van der Voort P H J, Uges D R A, van Roon E N, Brouwers J R B J
Department of Pharmacotherapy and Pharmaceutical Care, GUIDE, University of Groningen, Groningen, The Netherlands.
J Clin Pharm Ther. 2007 Dec;32(6):655-7. doi: 10.1111/j.1365-2710.2007.00861.x.
A case of a serious poisoning with the calcium entry blocker amlodipine is described, which was treated effectively with 4-aminopyridine. Calcium is suggested as general treatment of poisoning with calcium entry blockers in many guidelines. The use of intravenous 4-aminopyridine is theoretically useful to treat poisoning from calcium entry blockers and was demonstrated in this case report.
本文描述了一例因钙通道阻滞剂氨氯地平导致的严重中毒病例,该病例通过4-氨基吡啶得到有效治疗。在许多指南中,钙被推荐作为钙通道阻滞剂中毒的常规治疗方法。静脉注射4-氨基吡啶在理论上可用于治疗钙通道阻滞剂中毒,本病例报告对此进行了证实。