克氏锥虫中的信号转导机制。

Signal transduction mechanisms in Trypanosoma cruzi.

作者信息

Flawiá M M, Téllez-Iñón M T, Torres H N

机构信息

Instituto de investigaciones en Ingenieria Genética y Biología Molecular (CONICET and Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires), Vuelta de Obligado 2490. 1428 Buenos Aires, Argentina.

出版信息

Parasitol Today. 1997 Jan;13(1):30-3. doi: 10.1016/s0169-4758(96)10070-3.

DOI:10.1016/s0169-4758(96)10070-3

PMID:15275164

Abstract

Trypanosoma cruzi, the etiological agent of Chagas disease, is an adequate model for studies on the evolution of signal transduction pathways. These pathways involve molecular entities such as membrane receptors, transduction G proteins, protein kinases and second messengers (Ca(2+), cyclic AMP, cyclic GMP, nitric oxide). In this article, Mirtha M. Flawiá, María T. Téllez-Iñón and Héctor N. Torres describe the studies performed on T. cruzi transduction pathways and their role in the control of metacyclogenesis and cell motility.

摘要

克氏锥虫是恰加斯病的病原体，是研究信号转导通路进化的合适模型。这些通路涉及诸如膜受体、转导G蛋白、蛋白激酶和第二信使（钙离子、环磷酸腺苷、环磷酸鸟苷、一氧化氮）等分子实体。在本文中，米尔塔·M·弗拉维亚、玛丽亚·T·特列斯-伊尼翁和赫克托·N·托雷斯描述了对克氏锥虫转导通路及其在调控循环后期发育和细胞运动中的作用所进行的研究。