Hehl A, Roditi I
Institut für Allgemeine Mikrobiologie, Baltzerstrasse 4, CH-3012 Bern, Switzerland.
Parasitol Today. 1994 Nov;10(11):442-5. doi: 10.1016/0169-4758(94)90180-5.
The identification of procyclins as stage-specific coat proteins of procyclic forms of Trypanosoma brucei has not only provided a convenient molecular marker for the differentiation of bloodstream-form trypanosomes into procyclic forms, but has also allowed some important insights into gene regulation in trypanosomes. Here, Adrian Hehl and Isabel Roditi summarize what has been learnt in the past few years about the control mechanisms that may contribute to the stage-specific expression of procyclins.
亲环素被鉴定为布氏锥虫前循环型的阶段特异性表面蛋白,这不仅为将血流型锥虫分化为前循环型提供了一种便捷的分子标记,还使人们对锥虫的基因调控有了一些重要的认识。在此,阿德里安·黑尔和伊莎贝尔·罗迪蒂总结了过去几年中关于可能促成亲环素阶段特异性表达的调控机制所学到的知识。