Stebeck C E, Pearson T W
Department of Biochemistry and Microbiology, University of Victoria, British Columbia, Canada.
Exp Parasitol. 1994 Jun;78(4):432-6. doi: 10.1006/expr.1994.1050.
The procyclic stage in the life cycle of African trypanosomes is adapted for life in the harsh environment of the midgut of the tsetse fly vector. Procyclic forms derived by transformation from antigenically distinct bloodstream variants are antigenically similar and have lost the variant surface glycoprotein coat of the bloodstream forms. In contrast to bloodstream forms, where the variant surface glycoprotein coat is essentially the only molecule exposed, many different proteins can be labeled by surface iodination or biotinylation of procyclic trypanosomes. Despite this multiplicity of procyclic surface proteins, only a few have been characterized in any detail. This minireview focuses on one set of them, the predominant procyclins.
非洲锥虫生命周期中的前循环期适应于在采采蝇媒介中肠的恶劣环境中生存。通过从抗原性不同的血流变体转化而来的前循环型在抗原上相似，并且失去了血流型的可变表面糖蛋白外衣。与血流型不同，在血流型中可变表面糖蛋白外衣基本上是唯一暴露的分子，许多不同的蛋白质可以通过前循环锥虫的表面碘化或生物素化进行标记。尽管前循环表面蛋白具有多样性，但只有少数几种得到了详细的表征。本综述聚焦于其中一组，即主要的前循环素。
