Smith J A, Andreopoulou E
Department of Medicine, New York University School of Medicine and New York University Cancer Institute, New York, NY 10016, USA.
Ann Oncol. 2004;15 Suppl 1:I18-I26. doi: 10.1093/annonc/mdh653.
With breast cancer incidence rates showing no signs of abating, advances in risk stratification and increasing awareness of cancer control, there is interest in expanding the breast imaging arsenal. Mammography is still the standard of care, and a recent meta-analysis of seven large studies supports its value as a screening tool. There is, however, clear need for improved sensitivity and specificity. Imaging of function, metabolism and molecular activity in breast tissue is of potential benefit in addressing these issues. In this article we provide an overview of the current methods of imaging in breast cancer, including mammography, ultrasound, digital mammography, magnetic resonance, positron emission tomography and magnetic resonance spectroscopy. Screening and surveillance should, ideally, be tailored to an individual's cancer risk and breast tissue. Current evidence questions the recent move toward magnetic resonance imaging as a single or multimodality strategy for breast cancer screening. In a high-risk group, the cost effectiveness of technical innovations may be justified.
随着乳腺癌发病率毫无下降迹象,风险分层取得进展以及癌症控制意识不断提高,人们对扩充乳腺成像手段产生了兴趣。乳腺钼靶摄影仍是标准的护理手段,最近一项对七项大型研究的荟萃分析支持了其作为筛查工具的价值。然而,提高敏感性和特异性的需求十分明确。对乳腺组织的功能、代谢和分子活性进行成像可能有助于解决这些问题。在本文中,我们概述了目前乳腺癌的成像方法,包括乳腺钼靶摄影、超声、数字乳腺钼靶摄影、磁共振成像、正电子发射断层扫描和磁共振波谱分析。理想情况下,筛查和监测应根据个体的癌症风险和乳腺组织进行定制。目前的证据对最近将磁共振成像作为乳腺癌筛查的单一或多模态策略的做法提出了质疑。在高危人群中,技术创新的成本效益可能是合理的。