Jian Wushuai, Wu Mingshu, Shi Hongli, Wang Liting, Zhang Lu, Luo Shuqian
School of Biomedical Engineering, Capital Medical University, Beijing, China.
PLoS One. 2015 Apr 6;10(4):e0124143. doi: 10.1371/journal.pone.0124143. eCollection 2015.
To analyse the diagnostic signs present in slices of human breast tumour specimens using synchrotron radiation phase-contrast imaging computed tomography (PCI-CT) for the first time and assess the feasibility of this technique for clinical applications.
The ethics committee of our university and relevant clinical hospital approved this prospective study, and written informed consent was obtained from all patients. PCI-CT of human breast tumour specimens with synchrotron radiation was performed at the Shanghai Synchrotron Radiation Facility (SSRF). A total of 14 specimens of early-stage carcinomas and 8 specimens of adenomas were enrolled. Based on raw data reconstruction, the diagnostic signs present in the slices were analysed and correlated with histopathology. We proposed a criterion for clinical diagnosis according to the evaluated signs and the Breast Imaging Reporting and Data System (BI-RADS) for reference. The criterion was then assessed by clinicians in a double-blind method. Finally, descriptive statistics were evaluated, depending on the assessment results.
The 14 carcinoma specimens and 8 adenoma specimens were diagnosed as malignant and benign tumours, respectively. The total coincidence rate was 100%.
Our study results demonstrate that the X-ray diagnostic signs observed in the specimen slices and the criterion used for clinical diagnosis were accurate and reliable. The criterion based on signs analysis can be used to differentiate early-stage benign or malignant tumours. As a promising imaging method, PCI-CT can serve as a possible and feasible supplement to BI-RADS in the future.
首次使用同步辐射相衬成像计算机断层扫描（PCI-CT）分析人类乳腺肿瘤标本切片中的诊断征象，并评估该技术在临床应用中的可行性。
本前瞻性研究获得了我校伦理委员会和相关临床医院的批准，并获得了所有患者的书面知情同意书。在上海同步辐射装置（SSRF）对人类乳腺肿瘤标本进行同步辐射PCI-CT检查。共纳入14例早期癌标本和8例腺瘤标本。基于原始数据重建，分析切片中存在的诊断征象并与组织病理学进行关联。我们根据评估的征象和乳腺影像报告和数据系统（BI-RADS）提出了临床诊断标准以供参考。然后由临床医生采用双盲法对该标准进行评估。最后，根据评估结果进行描述性统计。
14例癌标本和8例腺瘤标本分别被诊断为恶性和良性肿瘤。总符合率为100%。
我们的研究结果表明，在标本切片中观察到的X线诊断征象以及用于临床诊断的标准准确可靠。基于征象分析的标准可用于鉴别早期良性或恶性肿瘤。作为一种有前景的成像方法，PCI-CT未来可作为BI-RADS的一种可能且可行的补充。
