Chankvetadze Bezhan
Molecular Recognition and Separation Science Laboratory, School of Chemistry, Tbilisi State University, Chavchavadze Ave 1, 380028 Tbilisi, Georgia.
Chem Soc Rev. 2004 Jul 30;33(6):337-47. doi: 10.1039/b111412n. Epub 2004 Jul 5.
This tutorial review describes the contribution of chiral capillary electrophoresis in combination with other instrumental techniques, especially nuclear magnetic resonance spectroscopy, to a better understanding of the chiral recognition mechanisms by cyclodextrins. Aspects such as affinity pattern of enantiomers towards various cyclodextrins as well as the stoichiometry of the resulting complexes, the equilibrium constants and the structure of complexes are addressed. In addition to the aforementioned techniques, the usefulness of complementary instrumental and molecular modeling techniques for an understanding of the chiral recognition mechanisms of cyclodextrins is also illustrated.
本教程综述描述了手性毛细管电泳与其他仪器技术（尤其是核磁共振光谱）相结合，在更好地理解环糊精的手性识别机制方面所做的贡献。文中讨论了对映体与各种环糊精的亲和模式、所得配合物的化学计量、平衡常数以及配合物的结构等方面。除了上述技术外，还说明了用于理解环糊精手性识别机制的互补仪器和分子建模技术的实用性。
