Mutignani M, Tringali A, Khodadadian E, Petruzziello L, Spada C, Spera G, Familiari P, Costamagna G
Digestive Endoscopy Unit, Catholic University, Rome, Italy.
Endoscopy. 2004 Aug;36(8):738-42. doi: 10.1055/s-2004-825672.
External pancreatic fistulas may follow abdominal surgery or injury. While most respond to conservative management or endoscopic intervention, others might require surgery for complete healing. We report four cases of patients with external pancreatic fistulas that failed to respond to conservative management and drainage. N-butyl-2-cyanoacrylate surgical glue (Glubran 2) was directly injected into the fistulous tract. The fistulas closed within 24 hours of the Glubran 2 injection in three cases (75 %). In patients with external pancreatic fistulas that fail to respond to conservative and endoscopic drainage, injection of Glubran 2 directly into the fistulous tract may lead to closure, thus avoiding the need for surgical intervention.
胰外瘘可能继发于腹部手术或外伤。虽然大多数患者对保守治疗或内镜干预有反应，但其他患者可能需要手术才能完全愈合。我们报告了4例胰外瘘患者，他们对保守治疗和引流均无反应。将N-丁基-2-氰基丙烯酸酯手术胶水（Glubran 2）直接注入瘘管。3例（75%）患者在注入Glubran 2后24小时内瘘管闭合。对于对保守治疗和内镜引流无反应的胰外瘘患者，将Glubran 2直接注入瘘管可能会使其闭合，从而避免手术干预的需要。
