Slimane Khemaies, Perez Adriana, Ruffié Pierre, di Palma Mario
Département de Médecine, Institut Gustave Roussy, rue Camille-Desmoulins, 94805 Villejuif Cedex.
Bull Cancer. 2004 May;91(5):403-8.
Nausea and vomiting are often seen in cancer patients. They can be acute (induced by chemotherapy or radiotherapy...), or chronic in patients with advanced disease. A high percentage of patients (70% to 80%) suffer from chemotherapy induced nausea and vomiting. The incidence and severity of these symptoms depend of the nature of chemotherapy, doses, other drugs used in association, and psychological status of the patients. International guidelines have improved the management of nausea and vomiting, with the use of new drugs like setrons. Despite this, optimal care of refractory and delayed nausea and vomiting after chemotherapy is still a matter of debate. Chronic nausea and vomiting concern more than 50% of patients in palliative situation. The origin is often multifactorial. Management consists in aetiologic and symptomatic treatment in order to improve the patients' quality of life.
恶心和呕吐在癌症患者中很常见。它们可能是急性的(由化疗或放疗引起……),也可能是晚期疾病患者的慢性症状。高比例的患者(70%至80%)会出现化疗引起的恶心和呕吐。这些症状的发生率和严重程度取决于化疗的性质、剂量、联合使用的其他药物以及患者的心理状态。国际指南通过使用如5-羟色胺受体拮抗剂等新药改善了恶心和呕吐的管理。尽管如此,化疗后难治性和迟发性恶心和呕吐的最佳护理仍是一个有争议的问题。在姑息治疗情况下,超过50%的患者存在慢性恶心和呕吐。其病因通常是多因素的。治疗包括病因治疗和对症治疗,以提高患者的生活质量。