从（-）-3-脱氢莽草酸或（-）-奎尼酸合成唾液酸（-）-KDN及某些差向异构体。

Synthesis of the sialic acid (-)-KDN and certain epimers from (-)-3-dehydroshikimic acid or (-)-quinic acid.

作者信息

Banwell Martin G, Hungerford Natasha L, Jolliffe Katrina A

机构信息

Research School of Chemistry, Institute of Advanced Studies, The Australian National University, Canberra, ACT 0200, Australia.

出版信息

Org Lett. 2004 Aug 5;6(16):2737-40. doi: 10.1021/ol049048y.

DOI:10.1021/ol049048y

PMID:15281757

Abstract

(-)-3-Dehydroshikimic acid (3-DHS, 4), a C(7)-building block now available in large quantity from corn syrup, has been converted into the sialic acid (-)-KDN (3) as well as its C-7- and C-8-epimers. (-)-Quinic acid can be used for the same purpose. [structure: see text]

摘要

(-)-3-脱氢莽草酸（3-DHS，4）是一种目前可从玉米糖浆大量获取的C(7)结构单元，已被转化为唾液酸(-)-KDN（3）及其C-7-和C-8-差向异构体。(-)-奎尼酸可用于相同目的。[结构：见正文]