(-)-3-脱氢莽草酸向(+)-对映体衍生物的转化。

Conversion of (-)-3-dehydroshikimic acid into derivatives of the (+)-enantiomer.

作者信息

Banwell Martin G, Edwards Alison J, Essers Michael, Jolliffe Katrina A

机构信息

Research School of Chemistry, Institute of Advanced Studies, The Australian National University, Canberra, ACT 0200, Australia.

出版信息

J Org Chem. 2003 Aug 22;68(17):6839-41. doi: 10.1021/jo034689c.

DOI:10.1021/jo034689c

PMID:12919063

Abstract

(-)-3-DHS (1), a compound available in large quantity through "engineering" of the shikimic acid pathway, has been converted over eight steps into the methyl ester, ent-2, of the (+)-enantiomer. Methyl (+)-shikimate (15) and its C-3 epimer (ent-5) have also been prepared by related means.

摘要

(-)-3-DHS（1）是一种可通过莽草酸途径“工程化”大量获得的化合物，已通过八步反应转化为（+）-对映体的甲酯ent-2。（+）-莽草酸甲酯（15）及其C-3差向异构体（ent-5）也已通过相关方法制备。