一种获得高对映体纯度的氨基酸、氨基醇或恶唑烷酮的立体发散方法。
A stereodivergent approach to amino acids, amino alcohols, or oxazolidinones of high enantiomeric purity.
作者信息
Spino Claude, Tremblay Marie-Claude, Godbout Cédrickx
机构信息
Département de Chimie, Université de Sherbrooke, 2500 Boulevard Université, Sherbrooke, Quebec, Canada J1K 2R1.
出版信息
Org Lett. 2004 Aug 5;6(16):2801-4. doi: 10.1021/ol048936q.
PMID:15281773
Abstract
(-)-Menthone, an inexpensive chiral auxiliary, was used to prepare both enantiomers of alpha-amino acids, amino alcohols, or oxazolidinones. The sequence includes the S(N)2' displacement by a cuprate reagent and a Curtius rearrangement as key steps.
摘要
（-）-薄荷酮，一种廉价的手性助剂，被用于制备α-氨基酸、氨基醇或恶唑烷酮的两种对映体。该反应序列包括铜酸盐试剂的S(N)2'取代反应和库尔提斯重排反应作为关键步骤。
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