一种合成手性非外消旋N-保护的α,α-二烷基化氨基酸的立体发散方法。
A stereodivergent approach to chiral nonracemic N-protected alpha,alpha-dialkylated amino acids.
作者信息
Spino Claude, Godbout Cédrickx
机构信息
Département de Chimie, Université de Sherbrooke, 2500 Boul. Université, Sherbrooke, QC, Canada, J1K 2R1.
出版信息
J Am Chem Soc. 2003 Oct 8;125(40):12106-7. doi: 10.1021/ja037078a.
PMID:14518992
Abstract
Menthyl carboxaldehyde is used as a chiral auxiliary to make quaternary amino acids of either configuration via a stereodivergent approach that includes an SN2' displacement by a cuprate reagent and a Curtius rearrangement as key steps.
摘要
薄荷醛用作手性助剂，通过一种立体发散方法制备两种构型的季铵氨基酸，该方法包括铜酸盐试剂的SN2'取代反应和库尔提斯重排反应作为关键步骤。
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