锰对大鼠离体主动脉收缩的抑制作用
Inhibitory effect of manganese on contraction of isolated rat aorta.
作者信息
Ettarh R R
机构信息
Department of Physiology, College of Medicine, University of Lagos, Idi-Araba, PMB 12003, Lagos, Nigeria.
出版信息
Indian J Exp Biol. 2004 Feb;42(2):149-51.
The effects of MnCl2 on vascular smooth muscle contraction induced by noradrenaline (NA) and KCl were investigated. Rings segments from rat aorta were isolated and changes in isometric tension recorded. MnCl2 (10 microM and 1 mM) significantly attenuated the contractile responses to NA and KCI. There were also reductions in the contractile responses to CaCl2 in NA- and KCl-stimulated rings, after pretreatment with MnCl2. The magnitude of the phasic contraction to NA was significantly reduced in presence of MnCl2. The results suggest that MnCl2 inhibits vascular smooth muscle contraction by influencing a Ca2+-mediated mechanism.
研究了氯化锰（MnCl₂）对去甲肾上腺素（NA）和氯化钾（KCl）诱导的血管平滑肌收缩的影响。分离大鼠主动脉的环段，记录等长张力的变化。MnCl₂（10微摩尔和1毫摩尔）显著减弱了对NA和KCl的收缩反应。在用MnCl₂预处理后，NA和KCl刺激的环段对氯化钙（CaCl₂）的收缩反应也有所降低。在存在MnCl₂的情况下，对NA的相性收缩幅度显著降低。结果表明，MnCl₂通过影响钙介导的机制来抑制血管平滑肌收缩。
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