Murray Veronica, Mårtensson Björn
Medicinska kliniken, Danderyds sjukhus, Stockholm, Sweden.
Lakartidningen. 2004 Jun 10;101(24):2108-10, 2112-3, 2115.
Emotional reactions are important sequelae of stroke. Mood disorders, such as depression, anxiety, post-traumatic stress syndrome and emotionalism, occur during the first post-stroke year, each of them in approximately 20-30% of patients. They often overlap, and prevalence estimates differ on account of differences in definitions; study populations; exclusion criteria and time of assessment. The risk seems to be greatest, at least for depression, in the first months after stroke. Some patients recover spontaneously but symptoms persist in up to one third. Pharmacological treatment can have a positive effect that also applies to rehabilitation, quality of life and cardiovascular mortality. However, study findings are not uniform and conclusive therapeutic and preventive intervention trials on mood disorders after stroke are urgently needed.
情绪反应是中风的重要后遗症。情绪障碍,如抑郁症、焦虑症、创伤后应激综合征和情感高涨,在中风后的第一年出现,每种情绪障碍在大约20% - 30%的患者中发生。它们常常相互重叠,由于定义、研究人群、排除标准和评估时间的不同,患病率估计也有所差异。至少对于抑郁症来说,中风后的头几个月风险似乎最大。一些患者会自发恢复,但症状会持续存在,多达三分之一的患者症状会持续。药物治疗可以产生积极效果,这也适用于康复、生活质量和心血管死亡率。然而,研究结果并不一致,迫切需要针对中风后情绪障碍进行确定性的治疗和预防性干预试验。