Fure Brynjar
Avdeling for geriatri, slag og rehabilitering, Sykehuset Asker og Baerum, 1309 Rud.
Tidsskr Nor Laegeforen. 2007 May 17;127(10):1387-9.
Emotional symptoms are probably among the most ignored impairments in stroke patients. Of these, depression is best described, and appears in 20-40% of the stroke patients. Other emotional symptoms are anxiety (20-30%), emotional instability (10-25%), crisis reaction (20%) and reduced initiative and fatigue (50-70%). Depression and anxiety are, according to some publications, related to organic lesions in the anterior parts of the left hemisphere, although this relationship is under discussion. In addition, marital status and neurological impairments correlate with emotional symptoms in stroke.
The manuscript is based on a Medline search (1980-2006) and on own clinical experience and research.
Several diagnostic instruments are in use to identify emotional symptoms in patients who suffer from stroke. Of these, the Montgomery-Asberg-Depression-Rating-Scale, the Geriatric Depression Scale and the Hospital Anxiety and Depression Scale are the most frequently used to diagnose post-stroke anxiety and depression in Norway. Aphasia and other cognitive impairments do however make these instruments difficult to use. At present, pharmacological treatment consists of selective serotonine reuptake inhibitors and serotonine noradrenaline reuptake inhibitors. Tricyclic antidepressive therapy is also effective, but often unsuitable due to side effects. Post-stroke emotional symptoms may affect the patients' neurological outcome, and should be emphasized more in the stroke unit. Documentation is insufficient regarding the effects of medical intervention, and more knowledge is needed.
情绪症状可能是中风患者中最被忽视的损伤之一。其中,抑郁症描述得最为详尽,在20%至40%的中风患者中出现。其他情绪症状包括焦虑(20%至30%)、情绪不稳定(10%至25%)、危机反应(20%)以及主动性降低和疲劳(50%至70%)。根据一些出版物,抑郁症和焦虑症与左半球前部的器质性病变有关,尽管这种关系仍在讨论中。此外,婚姻状况和神经功能障碍与中风患者的情绪症状相关。
本手稿基于对Medline(1980 - 2006年)的检索以及自身的临床经验和研究。
有几种诊断工具用于识别中风患者的情绪症状。其中,蒙哥马利 - 阿斯伯格抑郁评定量表、老年抑郁量表和医院焦虑抑郁量表是挪威最常用于诊断中风后焦虑和抑郁的工具。然而,失语症和其他认知障碍使得这些工具难以使用。目前,药物治疗包括选择性5-羟色胺再摄取抑制剂和5-羟色胺去甲肾上腺素再摄取抑制剂。三环类抗抑郁疗法也有效,但由于副作用往往不合适。中风后的情绪症状可能会影响患者的神经功能预后,在中风单元中应更加强调这一点。关于医学干预效果的记录不足,需要更多的知识。