Hadjiolov N, Zimmermann H P
Medical Academy, National Oncological Centre, Sofia, Bulgaria.
Neoplasma. 1992;39(3):147-50.
Two new monoclonal antibodies, E5/E10 and E10/B4, were raised which reacted with surface antigens on the metastatic rat pancreatic adenocarcinoma cell line ASML, but not with antigens localized on the cell surface of the nonmetastatic rat pancreatic adenocarcinoma line AS. These two monoclonal antibodies are of the IgG1 subclass and recognize protein bands with molecular weight 28,000 and 35,000 D. E5/E10 and E10/B4 cross-reacted only with antigens on the human colon cancer cell line HT-29, as well as with normal rat kidney.
制备了两种新的单克隆抗体E5/E10和E10/B4，它们与转移性大鼠胰腺腺癌细胞系ASML的表面抗原发生反应，但不与非转移性大鼠胰腺腺癌系AS细胞表面的抗原发生反应。这两种单克隆抗体属于IgG1亚类，识别分子量为28,000和35,000 D的蛋白条带。E5/E10和E10/B4仅与人结肠癌细胞系HT-29的抗原以及正常大鼠肾脏发生交叉反应。
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