高强度超声治疗钝性腹部实性器官损伤：动物模型
High-intensity ultrasound treatment of blunt abdominal solid organ injury: an animal model.
作者信息
Cornejo Carol J, Vaezy Shahram, Jurkovich Gregory J, Paun Marla, Sharar Sam R, Martin Roy W
机构信息
Department of Surgery, Harborview Medical Center, Univeristy of Washington, Seattle, Washington, USA.
出版信息
J Trauma. 2004 Jul;57(1):152-6. doi: 10.1097/01.ta.0000088009.93307.23.
BACKGROUND
High-intensity focused ultrasound (HIFU) is effective in producing hemostasis in injuries from organ lacerations and punctures in animals but has not been evaluated in impact injuries.
METHOD
High-energy blows were applied to 11 heparinized and anesthetized pigs, resulting in solid organ injury. HIFU was applied to injuries via laparotomy. The animals were closed, administered saline, observed under general anesthesia for 3.6 +/- 0.4 hours, reopened, and inspected, and abdominal free fluid was aspirated.
RESULTS
Organ hemostasis was achieved (mean +/- SD) with 15 +/- 6 minutes of HIFU treatment and 54 +/- 3 minutes of operating time, and 18.8 +/- 13.1 mL/kg of blood was recovered from the abdomen. One animal died from an untreated occult injury to a large vein. HIFU-treated sites were hemostatic at relaparotomy, with 8.6 +/- 6.2 mL/kg abdominal serosanguinous fluid recovered.
CONCLUSION
HIFU is effective in producing hemostasis by direct treatment of injured parenchyma in blunt trauma.
背景
高强度聚焦超声（HIFU）在动物器官撕裂伤和穿刺伤中止血有效，但尚未在冲击伤中进行评估。
方法
对11只肝素化并麻醉的猪施加高能打击，造成实体器官损伤。通过剖腹术对损伤部位应用HIFU。动物创口闭合，给予生理盐水，在全身麻醉下观察3.6±0.4小时，再次打开并检查，抽取腹腔游离液体。
结果
HIFU治疗15±6分钟、手术时间54±3分钟后实现器官止血，从腹腔回收18.8±13.1 mL/kg血液。1只动物死于未治疗的大静脉隐匿性损伤。再次剖腹术时，HIFU治疗部位止血，回收8.6±6.2 mL/kg腹腔浆液性血性液体。
结论
HIFU通过直接治疗钝性创伤中受损的实质组织来有效止血。
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