假定的肿瘤抑制基因gravin在慢性髓性白血病、骨髓增生异常综合征和急性髓性白血病中的低表达。

Low expression of the putative tumour suppressor gene gravin in chronic myeloid leukaemia, myelodysplastic syndromes and acute myeloid leukaemia.

作者信息

Boultwood Jacqueline, Pellagatti Andrea, Watkins Fiona, Campbell Lisa J, Esoof Noor, Cross Nicholas C P, Eagleton Helen, Littlewood Tim J, Fidler Carrie, Wainscoat James S

机构信息

Leukaemia Research Fund Molecular Haematology Unit, Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Oxford, UK.

出版信息

Br J Haematol. 2004 Aug;126(4):508-11. doi: 10.1111/j.1365-2141.2004.05067.x.

DOI:10.1111/j.1365-2141.2004.05067.x

PMID:15287943

Abstract

The putative tumour suppressor gene gravin is down-regulated in several solid tumours and is implicated in tumorigenesis. We have evaluated the expression levels of the gravin gene in the CD34(+)/blast cells of a range of myeloid malignancies as compared with controls using real-time quantitative polymerase chain reaction (PCR). Gravin was markedly down-regulated in 41 of 41 patients with acute myeloid leukaemia (AML), nine of 10 patients with myelodysplastic syndromes (MDS) and 33 of 33 patients with chronic myeloid leukaemia (CML), of whom 24 were in blast crisis (BC). We have shown that gravin is consistently down-regulated in the CD34(+)/blast cells of myeloid malignancies and may play a role in the molecular pathogenesis of these disorders.

摘要

假定的肿瘤抑制基因gravin在几种实体瘤中表达下调，并与肿瘤发生有关。我们使用实时定量聚合酶链反应（PCR）评估了一系列髓系恶性肿瘤的CD34(+)/原始细胞中gravin基因的表达水平，并与对照组进行了比较。在41例急性髓系白血病（AML）患者中的41例、10例骨髓增生异常综合征（MDS）患者中的9例以及33例慢性髓系白血病（CML）患者中的33例（其中24例处于急变期[BC]）中，gravin均明显下调。我们已经表明，gravin在髓系恶性肿瘤的CD34(+)/原始细胞中持续下调，可能在这些疾病的分子发病机制中起作用。