AKAP12 的生理和病理生理学作用。
Physiologic and pathophysiologic roles of AKAP12.
机构信息
Central Laboratory, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, P. R. China.
出版信息
Sci Prog. 2022 Jul-Sep;105(3):368504221109212. doi: 10.1177/00368504221109212.
A kinase anchoring protein (AKAP) 12 is a scaffolding protein that improves the specificity and efficiency of spatiotemporal signal through assembling intracellular signal proteins into a specific complex. AKAP12 is a negative mitogenic regulator that plays an important role in controlling cytoskeletal architecture, maintaining endothelial integrity, regulating glial function and forming blood-brain barrier (BBB) and blood retinal barrier (BRB). Moreover, elevated or reduced AKAP12 contributes to a variety of diseases. Complex connections between AKAP12 and various diseases including chronic liver diseases (CLDs), inflammatory diseases and a series of cancers will be tried to delineate in this paper. We first describe the expression, distribution and physiological function of AKAP12. Then we summarize the current knowledge of different connections between AKAP12 expression and various diseases. Some research groups have found paradoxical roles of AKAP12 in different diseases and further confirmation is needed. This paper aims to assess the role of AKAP12 in physiology and diseases to help lay the foundation for the design of small molecules for specific AKAP12 to correct the pathological signal defects.
蛋白激酶锚定蛋白 12（AKAP12）是一种支架蛋白，通过将细胞内信号蛋白组装到特定的复合物中，提高时空信号的特异性和效率。AKAP12 是一种负有丝分裂调节剂，在控制细胞骨架结构、维持内皮完整性、调节神经胶质功能以及形成血脑屏障（BBB）和血视网膜屏障（BRB）方面发挥着重要作用。此外，AKAP12 的升高或降低与多种疾病有关。本文试图阐述 AKAP12 与包括慢性肝病（CLD）、炎症性疾病和一系列癌症在内的各种疾病之间的复杂联系。我们首先描述了 AKAP12 的表达、分布和生理功能。然后，我们总结了 AKAP12 表达与各种疾病之间不同联系的现有知识。一些研究小组发现 AKAP12 在不同疾病中的作用存在矛盾，需要进一步证实。本文旨在评估 AKAP12 在生理和疾病中的作用，为设计特定 AKAP12 的小分子以纠正病理性信号缺陷奠定基础。
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