过氧化氢酶在妊娠山羊中布鲁氏菌毒力中的作用。

Role of catalase in the virulence of Brucella melitensis in pregnant goats.

作者信息

Gee Jason M, Kovach Michael E, Grippe Vanessa K, Hagius Sue, Walker Joel V, Elzer Philip H, Roop R Martin

机构信息

Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport 71130-3932, USA.

出版信息

Vet Microbiol. 2004 Aug 19;102(1-2):111-5. doi: 10.1016/j.vetmic.2004.05.009.

DOI:10.1016/j.vetmic.2004.05.009

PMID:15288933

Abstract

An isogenic katE mutant derived from virulent Brucella melitensis 16M displays hypersensitivity to hydrogen peroxide in disk sensitivity assays but retains the capacity to colonize pregnant goats and induce abortion. These experimental findings indicate that although the sole periplasmic catalase of Brucella melitensis functions as an antioxidant, this enzyme does not play a critical role in virulence in the natural host.

摘要

从强毒力的羊种布鲁氏菌16M衍生而来的同基因katE突变体，在纸片扩散药敏试验中对过氧化氢表现出超敏反应，但仍保留定殖于怀孕山羊并引发流产的能力。这些实验结果表明，尽管羊种布鲁氏菌唯一的周质过氧化氢酶具有抗氧化功能，但该酶在天然宿主的毒力方面并不起关键作用。