Elzer P H, Enright F M, McQuiston J R, Boyle S M, Schurig G G
Department of Veterinary Science, Louisiana State University Agricultural Center, Baton Rouge 70803, USA.
Res Vet Sci. 1998 May-Jun;64(3):259-60. doi: 10.1016/s0034-5288(98)90135-7.
Brucella melitensis strain VTRM1, a rough derivative of B melitensis strain 16M, is able to colonise the lymph nodes of goats, does not induce abortion in pregnant goats when used at doses leading to abortions with virulent strain 16M, and does not induce anti-O chain antibodies. However, strain VTRM1 as a single dose vaccine induces only partial protection against both infection and abortion following challenge.
布鲁氏菌 melitensis 菌株 VTRM1 是 B. melitensis 菌株 16M 的粗糙衍生物，能够在山羊的淋巴结中定殖，当以导致强毒株 16M 引起流产的剂量使用时，不会在怀孕山羊中诱导流产，也不会诱导抗 O 链抗体。然而，菌株 VTRM1 作为单剂量疫苗，在攻毒后仅能诱导部分抗感染和抗流产保护。
