δ样蛋白（Dlk）在一部分骨髓增生异常综合征骨髓切片中的过表达。

Overexpression of delta-like (Dlk) in a subset of myelodysplastic syndrome bone marrow trephines.

作者信息

Länger Florian, Stickel Juliane, Tessema Mathewos, Kreipe Hans, Lehmann Ulrich

机构信息

Institute of Pathology, Medizinische Hochschule Hannover, Carl-Neuberg-Strasse 1, Hannover, Germany.

出版信息

Leuk Res. 2004 Oct;28(10):1081-3. doi: 10.1016/j.leukres.2004.01.020.

DOI:10.1016/j.leukres.2004.01.020

PMID:15289021

Abstract

The mRNA expression level of the gene delta-like (Dlk), coding for a signal transducer related to the Delta-Notch family, was measured using real-time PCR methodology in a large series of control biopsies (n = 61) and bone marrow trephines from patients with myelodysplastic syndrome (MDS) (n = 93) and related myeloid disorders (AML, n = 16 and chronic myeloproliferative disease (CMPD), n = 38). It turned out that dlk is strongly overexpressed in a subset of MDS (16%) cases, however with higher frequency in blast rich MDS cases. Therefore, the quantitative detection of dlk mRNA can support the morphological diagnosis of MDS in selected cases.

摘要

利用实时聚合酶链反应方法，在大量对照活检样本（n = 61）以及骨髓穿刺活检样本中，检测了编码与Delta-Notch家族相关信号转导分子的基因delta样（Dlk）的信使核糖核酸（mRNA）表达水平。这些骨髓穿刺活检样本来自骨髓增生异常综合征（MDS）患者（n = 93）以及相关髓系疾病患者（急性髓系白血病，n = 16；慢性髓系增殖性疾病，n = 38）。结果表明，dlk在一部分MDS病例（16%）中强烈过表达，不过在原始细胞增多的MDS病例中频率更高。因此，dlk mRNA的定量检测在某些特定病例中可辅助MDS的形态学诊断。