Toninello A, Salvi M, Pietrangeli P, Mondovì B
Department of Biological Chemistry and CNR Center for the Study of Biomembranes, University of Padua, Padua, Italy.
Amino Acids. 2004 Jul;26(4):339-43. doi: 10.1007/s00726-004-0080-x. Epub 2004 Jun 11.
The programmed cell death is a very complex mechanism involving many factors, among them the intracellular concentration of biogenic amines (BA) appears to be important for apoptosis triggering. The mitochondrial damage is imputable to hydrogen peroxide and aldehydes, produced by amine oxidases (AO)-mediated oxidation of BA. On the other hands, the apoptosis protection observed by high BA concentration appears to be related to their scavenger effect of ROS and/or their interaction with membrane pores. Also monoamine oxidase (MAO) inhibitors, like propargylamines, preserve the mitochondria integrity by inhibiting MAO and therefore the production of H2O2 and aldehydes and, as cations, by regulating membrane pores, like BA. As general conclusion, apoptosis is protected by high concentration of BA and/or other cations while it is favoured by ROS produced by AOs or other mechanisms.
程序性细胞死亡是一种非常复杂的机制，涉及许多因素，其中生物胺（BA）的细胞内浓度似乎对凋亡触发很重要。线粒体损伤可归因于胺氧化酶（AO）介导的BA氧化产生的过氧化氢和醛。另一方面，高BA浓度所观察到的凋亡保护作用似乎与其对活性氧（ROS）的清除作用和/或其与膜孔的相互作用有关。同样，单胺氧化酶（MAO）抑制剂，如炔丙胺，通过抑制MAO从而抑制过氧化氢和醛的产生来维持线粒体完整性，并且作为阳离子，像BA一样调节膜孔。总的来说，高浓度的BA和/或其他阳离子可保护细胞凋亡，而AO或其他机制产生的ROS则促进细胞凋亡。
