Parslow David M, Rose David, Brooks Barbara, Fleminger Simon, Gray Jeffrey A, Giampietro Vincent, Brammer Michael J, Williams Steven, Gasston David, Andrew Christopher, Vythelingum Goparlen N, Loannou Glafkos, Simmons Andrew, Morris Robin G
King's College London, London, United Kingdom.
Neuropsychology. 2004 Jul;18(3):450-61. doi: 10.1037/0894-4105.18.3.450.
Hippocampal activation was investigated, comparing allocentric and egocentric spatial memory. Healthy participants were immersed in a virtual reality circular arena, with pattern-rendered walls. In a viewpoint-independent task, they moved toward a pole, which was then removed. They were relocated to another position and had to move to the prior location of the pole. For viewpoint-dependent memory, the participants were not moved to a new starting point, but the patterns were rotated to prevent them from indicating the final position. Hippocampal and parahippocampal activation were found in the viewpoint-independent memory encoding phase. Viewpoint-dependent memory did not result in such activation. These results suggest differential activation of the hippocampal formation during allocentric encoding, in partial support of the spatial mapping hypothesis as applied to humans.
研究了海马体激活情况,比较了以自我为中心和以环境为中心的空间记忆。健康参与者置身于一个带有图案渲染墙壁的虚拟现实圆形竞技场中。在一个与视角无关的任务中,他们朝着一根杆子移动,然后杆子被移除。他们被重新安置到另一个位置,必须移动到杆子之前的位置。对于与视角相关的记忆,参与者没有被移动到新的起始点,但图案被旋转以防止他们指出最终位置。在与视角无关的记忆编码阶段发现了海马体和海马旁回的激活。与视角相关的记忆并未导致这种激活。这些结果表明在以环境为中心的编码过程中海马结构的激活存在差异,部分支持了应用于人类的空间映射假说。