某些6H-吲哚并[2,3-b][1,8]萘啶衍生物的合成及细胞生长抑制特性
Synthesis and cytostatic properties of some 6H-Indolo[2, 3-b][1, 8]naphthyridine derivatives.
作者信息
Mastalarz Henryk, Jasztold-Howorko Ryszard, Rulko Felicja, Croisy Alain, Carrez Daniele
机构信息
Department of Organic Chemistry, University of Medicine, Wrocław, Poland.
出版信息
Arch Pharm (Weinheim). 2004 Aug;337(8):434-9. doi: 10.1002/ardp.200200696.
The new and efficient synthesis of the title heterocyclic ring system is described starting from suitable 2-chloro-1, 8-naphthyridines. The synthesized 6H-indolo[2, 3-b][1, 8]naphthyridine derivatives were tested in vitro on 55 tumor cell lines for their anticancer properties. The presence of the acetylamino moiety at position 3 in the main ring system proved to be crucial for the cytostatic activity of this class of compounds.
本文描述了从合适的2-氯-1,8-萘啶出发，对标题杂环体系进行的新型高效合成方法。所合成的6H-吲哚并[2,3-b][1,8]萘啶衍生物在体外对55种肿瘤细胞系进行了抗癌特性测试。结果表明，主环体系中3位乙酰氨基部分的存在对这类化合物的细胞生长抑制活性至关重要。
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