Cai Jianwen, Schaubel Douglas E
Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7420, USA.
Lifetime Data Anal. 2004 Jun;10(2):121-38. doi: 10.1023/b:lida.0000030199.23383.45.
Recurrent events are frequently observed in biomedical studies, and often more than one type of event is of interest. Follow-up time may be censored due to loss to follow-up or administrative censoring. We propose a class of semi-parametric marginal means/rates models, with a general relative risk form, for assessing the effect of covariates on the censored event processes of interest. We formulate estimating equations for the model parameters, and examine asymptotic properties of the parameter estimators. Finite sample properties of the regression coefficients are examined through simulations. The proposed methods are applied to a retrospective cohort study of risk factors for preschool asthma.
在生物医学研究中经常观察到复发事件,并且通常不止一种类型的事件是令人感兴趣的。由于失访或行政审查,随访时间可能会被截尾。我们提出了一类半参数边际均值/率模型,具有一般相对风险形式,用于评估协变量对感兴趣的截尾事件过程的影响。我们为模型参数制定估计方程,并研究参数估计量的渐近性质。通过模拟检验回归系数的有限样本性质。所提出的方法应用于一项关于学龄前哮喘危险因素的回顾性队列研究。