Pimenov I V, Zaĭtseva N S, Volkolakova R Iu
Vestn Oftalmol. 1992 Mar-Apr;108(2):27-30.
Hemostasis studies of 152 patients with inflammatory dystrophic and circulatory diseases of the retina and the uveal tract have shown that the major hemostasis disorders consisted in the presence of soluble fibrin monomer complexes in the blood of 62-90.5% of patients and in retarded lysis of the blood euglobulin fraction. Patients with the above hemostasis disorders and central serous chorioretinopathies and abiotrophies develop delayed formation of the fibrin clot and its poor retraction, that is characteristic of latent imbalance of the coagulation and fibrinolysis processes and liability to DIC. Patients with retinal vein thrombosis develop, besides delayed fibrin polymerization in the clot and reduction of platelet contractility, a drastic depression of the blood and lacrimal fibrinolytic activity. Central choroiditis and uveitis was associated with a marked increase of lacrimal fibrinolysis and reduced blood plasma fibrinolysis, along with enhanced paracoagulation and prolonged lysis of the blood euglobulin fraction, this resulting in hypoproteolytic hypercoagulation. Local and systemic fibrinolysis test may help choose the drugs for local and general pathogenetic therapy.
对152例患有视网膜和葡萄膜炎症性营养不良及循环系统疾病的患者进行的止血研究表明，主要的止血障碍包括62%至90.5%的患者血液中存在可溶性纤维蛋白单体复合物以及血液优球蛋白部分溶解延迟。患有上述止血障碍以及中心性浆液性脉络膜视网膜病变和营养障碍的患者，纤维蛋白凝块形成延迟且回缩不良，这是凝血和纤维蛋白溶解过程潜在失衡以及易发生弥散性血管内凝血的特征。视网膜静脉血栓形成患者除了凝块中纤维蛋白聚合延迟和血小板收缩力降低外，血液和泪液纤维蛋白溶解活性也显著降低。中心性脉络膜炎和葡萄膜炎与泪液纤维蛋白溶解显著增加、血浆纤维蛋白溶解降低有关，同时副凝血增强和血液优球蛋白部分溶解时间延长，导致低蛋白水解性高凝状态。局部和全身纤维蛋白溶解试验有助于选择局部和全身病因治疗的药物。
