Wells T, Balment R J
Department of Physiological Sciences, University of Manchester, UK.
Acta Endocrinol (Copenh). 1992 Aug;127(2):174-8. doi: 10.1530/acta.0.1270174.
The effects of chronic and acute changes in plasma composition on the osmolality and sodium concentration of cerebrospinal fluid and plasma vasopressin (AVP) concentration have been examined. Chronic elevation of plasma osmolality in three strains of genetically AVP-deficient rats (Brattleboro and New Zealand hypertensive and normotensive Brattleboro) was associated with increased cerebrospinal fluid osmolality by comparison with AVP-replete controls (Long Evans and New Zealand genetically hypertensive and normotensive rats). The linear correlation between plasma and cerebrospinal fluid osmolality did not reflect a similar relationship between plasma and cerebrospinal fluid sodium concentration. Hypertensive animals exhibited a threefold higher plasma AVP concentration in association with significantly elevated cerebrospinal fluid osmolality by comparison with normotensive controls. Although ip hypertonic saline injection elicited parallel increases in plasma and cerebrospinal fluid osmolality and sodium concentration in both hypertensive and normotensive rats, only in the normotensives did this result in an increase in plasma AVP concentration. These results indicate that cerebrospinal fluid is subject to modest chronic and acute changes in osmolality and sodium concentration which may contribute to the osmotic control of AVP secretion. The disturbed control of vasopressin secretion in hypertensive rats may in part be related to the abnormal cerebrospinal fluid composition in these animals.
研究了血浆成分的慢性和急性变化对脑脊液渗透压、钠浓度以及血浆血管加压素（AVP）浓度的影响。与血管加压素充足的对照动物（长 Evans 大鼠以及新西兰遗传性高血压和正常血压大鼠）相比，三种遗传性血管加压素缺乏大鼠品系（布拉特洛维大鼠以及新西兰高血压和正常血压的布拉特洛维大鼠）血浆渗透压的慢性升高与脑脊液渗透压升高有关。血浆渗透压与脑脊液渗透压之间的线性相关性并未反映出血浆钠浓度与脑脊液钠浓度之间的类似关系。与正常血压对照动物相比，高血压动物的血浆 AVP 浓度高出三倍，同时脑脊液渗透压显著升高。尽管腹腔注射高渗盐水可使高血压和正常血压大鼠的血浆和脑脊液渗透压及钠浓度同时升高，但只有正常血压大鼠的血浆 AVP 浓度会因此增加。这些结果表明，脑脊液的渗透压和钠浓度会发生适度的慢性和急性变化，这可能有助于对血管加压素分泌进行渗透调节。高血压大鼠中血管加压素分泌的调节紊乱可能部分与这些动物脑脊液成分异常有关。
