Suppr超能文献

大鼠主动脉阻断-再灌注后的肺损伤:氯化钆的作用。

Lung injury after aortic occlusion-reperfusion in rats: the role of gadolinium chloride.

作者信息

Okutan Huseyin, Savas Cagri, Ozguner I Faruk, Yonden Zafer, Eren V Cagatay, Delibas Namik

机构信息

Department of Cardiovascular Surgery, Süleyman Demirel University Medical School, Isparta, Turkey.

出版信息

Tohoku J Exp Med. 2004 Aug;203(4):267-73. doi: 10.1620/tjem.203.267.

Abstract

Aortic ischemia-reperfusion (AIR) induced lung injury has already been documented. Kupffer cell blockage (KCB) with gadolinium chloride (GdCl3) has also been shown to attenuate remote organ damage caused by ischemia reperfusion. The present study was designed to examine the effect of GdCl3 in lung ischemia-reperfusion injury induced by aortic occlusion. Thirty-two rats were randomly allocated to four groups as follows: SHAM (Sham Laparotomy), SHAM+KCB, AIR, and AIR+KCB. An atraumatic microvascular clamp was placed across the infrarenal abdominal aorta just after its origin from the aorta for 30 minutes. The microvascular clamp on the infrarenal abdominal aorta was removed and reperfused for 60 minutes. GdCl3 was given 24 hours prior to the experiment. Malondialdehyde (MDA) level and myeloperoxidase (MPO) activity were assayed in lung tissues. MDA level and MPO activity in the AIR group were significantly higher than those in the other groups. When compared to AIR group, KCB with GdCl3 significantly decreased MDA level and MPO activity in the AIR+KCB group. These results suggest that GdCl3 attenuates the lung injury caused by AIR. The effects of GdCl3 on reduced lung damage may be mediated through significant decreases in both MDA level and MPO activity.

摘要

主动脉缺血再灌注(AIR)诱导的肺损伤已有文献记载。用氯化钆(GdCl3)阻断库普弗细胞(KCB)也已显示可减轻缺血再灌注引起的远隔器官损伤。本研究旨在探讨GdCl3在主动脉阻断诱导的肺缺血再灌注损伤中的作用。32只大鼠随机分为以下四组:假手术组(假剖腹术)、假手术+KCB组、AIR组和AIR+KCB组。在肾下腹主动脉自主动脉起始处之后立即用无创微血管夹夹闭30分钟。移除肾下腹主动脉上的微血管夹并再灌注60分钟。在实验前24小时给予GdCl3。测定肺组织中的丙二醛(MDA)水平和髓过氧化物酶(MPO)活性。AIR组的MDA水平和MPO活性显著高于其他组。与AIR组相比,GdCl3进行KCB可显著降低AIR+KCB组的MDA水平和MPO活性。这些结果表明,GdCl3可减轻AIR所致的肺损伤。GdCl3对减轻肺损伤的作用可能是通过显著降低MDA水平和MPO活性来介导的。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验