中央杏仁核和背侧纹状体的N-甲基-D-天冬氨酸受体参与工具性学习和自发行为。
Central amygdalar and dorsal striatal NMDA receptor involvement in instrumental learning and spontaneous behavior.
作者信息
Andrzejewski Matthew E, Sadeghian Kenneth, Kelley Ann E
机构信息
Department of Psychiatry, University of Wisconsin-Madison Medical School, Madison, WI 53719, USA.
出版信息
Behav Neurosci. 2004 Aug;118(4):715-29. doi: 10.1037/0735-7044.118.4.715.
Abstract
Glutamate-coded signaling in corticostriatal circuits has been shown to be important in various forms of learning and memory. In the present study, the authors found that N-methyl-D-aspartate (NMDA) receptor antagonism in the central nucleus of the amygdala (CeA) and the posterior lateral striatum (PLS) impaired instrumental conditioning but had no effect in the anterior dorsal striatum. NMDA receptor antagonism in the CeA and PLS also affected spontaneous motor behavior and certain aspects of feeding. The present findings extend knowledge of the dynamic neurophysiological processes, instantiated in a complex neural network, required for instrumental learning in the mammalian brain.
摘要
在皮质纹状体回路中，谷氨酸编码的信号传导已被证明在各种形式的学习和记忆中起着重要作用。在本研究中，作者发现杏仁核中央核（CeA）和后外侧纹状体（PLS）中的N-甲基-D-天冬氨酸（NMDA）受体拮抗作用损害了工具性条件反射，但对背侧前纹状体没有影响。CeA和PLS中的NMDA受体拮抗作用也影响自发运动行为和进食的某些方面。本研究结果扩展了对哺乳动物大脑中工具性学习所需的复杂神经网络中实例化的动态神经生理过程的认识。
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