前强啡肽原启动子多态性与中国人群精神分裂症相关。
Polymorphism of Prodynorphin promoter is associated with schizophrenia in Chinese population.
作者信息
Zhang Chang-Shun, Tan Zheng, Lu Lan, Wu Sheng-Nan, He Ying, Gu Niu-Fan, Feng Guo-Yin, He Lin
机构信息
Bio-X Life Science Research Center, Shanghai Jiao Tong University, Shanghai 200030, China.
出版信息
Acta Pharmacol Sin. 2004 Aug;25(8):1022-6.
AIM
To investigate the correlation between single nucleotide polymorphisms (SNPs) of functional candidate gene Prodynorphin (PDYN) and schizophrenia.
METHODS
SNPs in the promoter and exon regions of PDYN were screened and genotyped for association study in a cohort of Chinese Han schizophrenia cases and controls.
RESULTS
Two SNPs PDYN-1576C>T and PDYN-946C>G were identified in the promoter region but PDYN-946C>G showed significant differences of allele distribution (x2=6.15, P=0.013) and genotype distribution (x2=6.87, P=0.032) between schizophrenic and control subjects.
CONCLUSION
PDYN-946C>G polymorphism demonstrated an association with population susceptibility to schizophrenia.
目的
研究功能候选基因强啡肽原（PDYN）的单核苷酸多态性（SNP）与精神分裂症之间的相关性。
方法
对中国汉族精神分裂症病例组和对照组人群进行研究，筛选PDYN启动子和外显子区域的SNP并进行基因分型，以进行关联研究。
结果
在启动子区域鉴定出两个SNP，即PDYN-1576C>T和PDYN-946C>G，但PDYN-946C>G在精神分裂症患者和对照受试者之间的等位基因分布（x2=6.15，P=0.013）和基因型分布（x2=6.87，P=0.032）存在显著差异。
结论
PDYN-946C>G多态性与人群对精神分裂症的易感性相关。
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