de Wit M C Y, de Bruin H G, Eijkenboom W, Sillevis Smitt P A E, van den Bent M J
Department of Neuro-oncology/Neurology, Daniel den Hoed Cancer Center/Erasmus Medical Center, Rotterdam, The Netherlands.
Neurology. 2004 Aug 10;63(3):535-7. doi: 10.1212/01.wnl.0000133398.11870.9a.
To determine the frequency of progressive MRI lesions shortly after radiotherapy for glioma with spontaneous improvement or stabilization, the authors studied a cohort of patients treated within two prospective phase III trials with radiotherapy only. In 9 out of 32 patients, the first post-radiotherapy MRI showed progressive enhancement. In 3 of these 9 the MRI improved or stabilized for 6 months without additional treatment. The authors conclude that patients with progressive lesions within 3 months after radiotherapy should not be eligible for phase II trials on recurrent glioma.
为了确定胶质瘤放疗后短期内出现的、有自发改善或稳定情况的进行性MRI病变的频率，作者研究了一组仅接受放疗的前瞻性III期试验中的患者队列。在32例患者中，有9例放疗后的首次MRI显示有进行性强化。在这9例中的3例患者，MRI在未接受额外治疗的情况下改善或稳定了6个月。作者得出结论，放疗后3个月内出现进行性病变的患者不应纳入复发性胶质瘤的II期试验。
