妊娠引起的拉莫三嗪药代动力学变化：一项单药治疗研究。

Gestation-induced changes in lamotrigine pharmacokinetics: a monotherapy study.

作者信息

de Haan G-J, Edelbroek P, Segers J, Engelsman M, Lindhout D, Dévilé-Notschaele M, Augustijn P

机构信息

Department of Neurology and Epileptology, Epilepsy Institute of the Netherlands SEIN, Heemstede, The Netherlands.

出版信息

Neurology. 2004 Aug 10;63(3):571-3. doi: 10.1212/01.wnl.0000133213.10244.fd.

DOI:10.1212/01.wnl.0000133213.10244.fd

PMID:15304599

Abstract

The authors describe 12 pregnancies in women with epilepsy using lamotrigine (LTG) monotherapy. A seizure increase in nine pregnancies was probably related to a gradual decline of LTG level-to-dose ratio to 40% of baseline. After delivery, LTG kinetics returned swiftly to baseline, causing toxic side effects in some women. Frequent LTG level monitoring and appropriate dose adjustments are advised in the period before and during pregnancy and after delivery, especially in women on LTG monotherapy.

摘要

作者描述了12例使用拉莫三嗪（LTG）单药治疗的癫痫女性的妊娠情况。9例妊娠期间癫痫发作增加可能与LTG血药浓度与剂量比值逐渐降至基线的40%有关。分娩后，LTG的药代动力学迅速恢复至基线水平，导致部分女性出现毒性副作用。建议在妊娠前、妊娠期间及分娩后频繁监测LTG血药浓度并进行适当的剂量调整，尤其是对于接受LTG单药治疗的女性。