Papageorgiou Charalabos C, Alevizos Basil, Ventouras Erricos, Kontopantelis Evagelos, Uzunoglu Nikolaos, Christodoulou George
Department of Psychiatry, University of Athens, Eginition Hospital, 74 Vas. Sophias Ave., Athens 11528, Greece.
J Affect Disord. 2004 Aug;81(2):147-52. doi: 10.1016/S0165-0327(03)00136-8.
Psychotic major depression (PMD) and delusional misidentification syndromes (DMS) exhibit cognitive deficits. Since the P300 component of event-related potentials (ERPs) provides valuable information concerning cognition, we studied this component of ERPs in DMS and PMD patients.
Nine patients with DMS, 15 patients with PMD, and 11 healthy controls, matched for age, sex and educational level, were tested using the auditory P300 component of ERPs.
Both patient groups showed significant reductions in P300 amplitude at the right frontal region, while DMS group showed significant attenuation of the P300 amplitude at the right parietal area. P300 latency was significantly prolonged in the central midline brain region in the DMS group.
The smallness of the sample size and the hypothetical post-hoc assignation of psychological function to regional activation.
PMD and DMS patients may share similar psychophysiological alterations connected to the right frontal region, mediating automatic processes, while DMS are associated with dysfunction of effortful mechanisms and allocation of attentional resources involving the interhemispheric and right parietal circuitry.
伴有精神病性症状的重度抑郁症（PMD）和妄想性错认综合征（DMS）存在认知缺陷。由于事件相关电位（ERP）的P300成分能提供有关认知的有价值信息，我们对DMS和PMD患者的该ERP成分进行了研究。
使用ERP的听觉P300成分对9例DMS患者、15例PMD患者以及11名年龄、性别和教育水平相匹配的健康对照者进行测试。
两组患者右侧额叶区域的P300波幅均显著降低，而DMS组右侧顶叶区域的P300波幅显著衰减。DMS组中央中线脑区的P300潜伏期显著延长。
样本量小以及对区域激活进行心理功能的假设性事后归因。
PMD和DMS患者可能具有与右侧额叶区域相关的相似心理生理改变，介导自动过程，而DMS与涉及半球间和右侧顶叶回路的努力机制功能障碍及注意力资源分配有关。
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