Ortiz Alonso T, Pérez-Serrano J M, Zaglul Zaiter C, Coullaut García J, Coullaut García R, Criado Rodríguez J
Departamento de Psiquiatría, Facultad de Medicina, Universidad Complutense de Madrid, Spain.
Actas Esp Psiquiatr. 2002 Jan-Feb;30(1):1-6.
Event related potentials are an objective parameter reflecting cognitive functions. Among the event related potentials, the P300 component is viewed as a measure of stimulus evaluation time and it can provide a rough estimate of the time required for perceptual processing. Impairment in cognitive processing, psychomotor retardation and abnormally amplitude and longer P300 latency have been found in depressive patients.
To evaluate the influence of visual and auditory stimuli on the P300 latency we studied 595 patients with major depression. The experimental tasks applied were, first, a series of 300 auditory stimuli: 85% were tones of 1,000 Hz, and 15% were tones of 2,000 Hz, and second, a series of 300 visual stimuli; 85% were black circles on a white background and 15% were black squares on a white background.
The results shown an increase of P300 latency in depressive patients during auditory and visual tasks.
These results are consistent with an impairment in brain function with cortical hypo activity in depressive patients that is associated with cognitive deficit processing. These results determine the clinical utility of P300 in patients with major depression.
事件相关电位是反映认知功能的客观参数。在事件相关电位中，P300成分被视为刺激评估时间的一种度量，它可以对感知处理所需时间提供一个粗略估计。在抑郁症患者中已发现认知处理受损、精神运动迟缓以及P300波幅异常和潜伏期延长。
为评估视觉和听觉刺激对P300潜伏期的影响，我们研究了595例重度抑郁症患者。所应用的实验任务，首先是一系列300个听觉刺激：85%为1000赫兹的音调，15%为2000赫兹的音调；其次是一系列300个视觉刺激，85%是白色背景上的黑色圆圈，15%是白色背景上的黑色方块。
结果显示抑郁症患者在听觉和视觉任务期间P300潜伏期增加。
这些结果与抑郁症患者大脑功能受损及皮质活动减退一致，这与认知缺陷处理有关。这些结果确定了P300在重度抑郁症患者中的临床效用。
