Seprafilm在预防硬膜外纤维化方面优于Gore-Tex。

Seprafilm superior to Gore-Tex in the prevention of peridural fibrosis.

作者信息

Topsakal Cahide, Akpolat Nusret, Erol Fatih Serhat, Ozveren Mehmet Faik, Akdemir Ismail, Kaplan Metin, Tiftikci Murat, Kilic Nermin

机构信息

Department of Neurosurgery, Firat University, School of Medicine, Elazig, Turkey.

出版信息

J Neurosurg. 2004 Aug;101(2):295-302. doi: 10.3171/jns.2004.101.2.0295.

DOI:10.3171/jns.2004.101.2.0295

PMID:15309922

Abstract

OBJECT

This is an investigation into the effects of two barrier membranes in the prevention of peridural fibrosis in an animal model.

METHODS

Seprafilm or Gore-Tex was applied to a laminectomy defect overlying the dura mater in rats separated into treatment groups. A third group of rats underwent laminectomy only and served as controls. Two months postoperatively a histological study was performed to compare the amount of scar tissue in each group. The gross dissection demonstrated that both membranes created a controlled dissection plane, facilitated access to the epidural space, and provided a reduction in the amount of tissue adhering to the dura mater. Statistically, Seprafilm was superior to Gore-Tex in preventing peridural fibrosis (p < 0.05).

CONCLUSIONS

Seprafilm can prevent peridural fibrosis better than Gore-Tex and can be used in humans in spinal surgery.

摘要

目的

本研究旨在探讨两种屏障膜在动物模型中预防硬膜外纤维化的效果。

方法

将大鼠分为治疗组，在覆盖硬脑膜的椎板切除缺损处应用Seprafilm或戈尔特斯（Gore-Tex）。第三组大鼠仅接受椎板切除术作为对照。术后两个月进行组织学研究，比较每组瘢痕组织的量。大体解剖显示，两种膜均形成了一个可控的解剖平面，便于进入硬膜外间隙，并减少了附着于硬脑膜的组织量。统计学上，Seprafilm在预防硬膜外纤维化方面优于戈尔特斯（Gore-Tex）（p < 0.05）。