Sandoval Manuel A, Hernandez-Vaquero Daniel
Hospital San Agustín, Avilés, Asturias, Spain.
, C/ Cabruñana, 48-1 A, 33400, Avilés, Spain.
Eur Spine J. 2008 Mar;17(3):451-455. doi: 10.1007/s00586-007-0580-y. Epub 2008 Jan 3.
Peridural fibrosis is one of the more frequent complications of lumbar surgery. Nonsteroidal anti-inflammatory drugs inhibit the inflammatory and fibroblastic response. We performed lumbar laminectomies in 24 rabbits, divided into two groups. The experimental group received 5 mg/kg/day of aceclofenac for 7 days and the control group received 1 cm(3) of physiological saline. The samples were stained using immunohistochemical methods. The cellular populations in the inflammatory reaction and the thickness of the fibrous membrane were quantified. The mean of the fibrous area was always less in the rabbits of the experimental group compared to controls (47% less at 2 weeks and 41% less at 4 weeks). We observed an 8% decrease in the number of fibroblasts with antivimentin monoclonal antibodies in the experimental group. In this model, aceclofenac inhibits the presence of inflammatory cells in the fibrous scar in the early stages and reduces the extension of adhesions without adverse reactions.
硬膜外纤维化是腰椎手术较为常见的并发症之一。非甾体类抗炎药可抑制炎症和成纤维细胞反应。我们对24只兔子进行了腰椎椎板切除术，并将其分为两组。实验组连续7天接受每日5mg/kg的醋氯芬酸治疗，对照组接受1cm³生理盐水。样本采用免疫组化方法染色。对炎症反应中的细胞群体和纤维膜厚度进行定量分析。与对照组相比，实验组兔子的纤维面积平均值始终较小（2周时减少47%，4周时减少41%）。我们观察到实验组中抗波形蛋白单克隆抗体标记的成纤维细胞数量减少了8%。在该模型中，醋氯芬酸在早期可抑制纤维瘢痕中炎症细胞的存在，并减少粘连范围，且无不良反应。
