Li Shilian, Liu Xiaolan, Okada Tomoo, Iwata Fujihiko, Hara Mitsuhiko, Harada Kensuke
Beijing Children's Hospital Affiliated with Capital University of Medical Sciences, Beijing, People's Republic of China.
Pediatr Int. 2004 Aug;46(4):425-8. doi: 10.1111/j.1442-200x.2004.01908.x.
The aim of the present study was to examine the serum lipid profile in obese Chinese children, their serum lipid and apolipoprotein A-I (apoA-I) and B (apoB) levels were examined.
The subjects were 153 patients (109 male and 44 female) aged 4-16 years with obesity, who attended the outpatient clinic of Beijing Children's Hospital. Percentage bodyweight (%BW) ([(bodyweight - standard weight)/standard weight]x 100) were obtained. Skinfold thickness and hip and waist circumference were measured. Percentage body fat (%BF) was estimated by bioelectrical impedance analyzer. Serum total cholesterol (TC), high density lipoprotein cholesterol (HDLC), triglyceride (TG), apoA-I and apoB levels were also measured.
TC showed an acceptable level in 86.8% of obese children. The prevalence of high TC levels (3.3%) or high LDLC levels (6.0%) was rather low. The HDLC level was reduced in 31.3% of obese children. Anthropometric variables had no linear relationship to TC, HDLC, TG, LDLC, apoA-I or apoB, but in the older age group (over 10 years old) %BW and %BF showed a weak correlation with HDLC (r = -0.202, r = -0.211, respectively).
In obese Chinese children, HDLC as well as TC levels should be examined in order to assess coronary risk.
本研究旨在检测肥胖中国儿童的血脂谱，检测他们的血脂、载脂蛋白A-I（apoA-I）和载脂蛋白B（apoB）水平。
研究对象为153例4至16岁的肥胖门诊患儿（男109例，女44例），来自北京儿童医院。计算体重百分比（%BW）[（体重-标准体重）/标准体重×100]，测量皮褶厚度、臀围和腰围，用生物电阻抗分析仪估算体脂百分比（%BF），同时检测血清总胆固醇（TC）、高密度脂蛋白胆固醇（HDLC）、甘油三酯（TG）、apoA-I和apoB水平。
86.8%的肥胖儿童TC水平正常，高TC水平（3.3%）或高低密度脂蛋白胆固醇（LDLC）水平（6.0%）的患病率较低，31.3%的肥胖儿童HDLC水平降低。人体测量学变量与TC、HDLC、TG、LDLC、apoA-I或apoB无线性关系，但在年龄较大组（10岁以上），%BW和%BF与HDLC呈弱相关（分别为r = -0.202，r = -0.211）。
对于肥胖中国儿童，应检测HDLC和TC水平以评估冠心病风险。
