Acton Ronald T, Barton Ellen H, Hollowell William W, Dreibelbis Amy L, Go Rodney C P, Barton James C
Immunogenetics Program and Departments of Microbiology, University of Alabama at Birmingham, Alabama, USA.
BMC Cancer. 2004 Aug 13;4:47. doi: 10.1186/1471-2407-4-47.
We sought to evaluate the hypothesis that the high incidence of cutaneous melanoma in white persons in central Alabama is associated with a predominance of Irish and Scots descent.
Frequencies of country of ancestry reports were tabulated. The reports were also converted to scores that reflect proportional countries of ancestry in individuals. Using the scores, we computed aggregate country of ancestry indices as estimates of group ancestry composition. HLA-DRB104 allele frequencies and relationships to countries of ancestry were compared in probands and controls. Results were compared to those of European populations with HLA-DRB104 frequencies.
Ninety evaluable adult white cutaneous melanoma probands and 324 adult white controls reported countries of ancestry of their grandparents. The respective frequencies of Ireland, and Scotland and "British Isles" reported countries of ancestry were significantly greater in probands than in controls. The respective frequencies of Wales, France, Italy and Poland were significantly greater in controls. 16.7% of melanoma probands and 23.8% of controls reported "Native American" ancestry; the corresponding "Native American" country of ancestry index was not significantly different in probands and controls. The frequency of HLA-DRB104 was significantly greater in probands, but was not significantly associated with individual or aggregate countries of ancestry. The frequency of DRB104 observed in Alabama was compared to DRB1*04 frequencies reported from England, Wales, Ireland, Orkney Island, France, Germany, and Australia.
White adults with cutaneous melanoma in central Alabama have a predominance of Irish, Scots, and "British Isles" ancestry and HLA-DRB1*04 that likely contributes to their high incidence of cutaneous melanoma.
我们试图评估阿拉巴马州中部白人皮肤黑色素瘤高发病率与爱尔兰和苏格兰血统占主导地位这一假设之间的关系。
将祖先所在国家报告的频率制成表格。这些报告还被转换为反映个体祖先比例国家的分数。利用这些分数，我们计算了祖先国家综合指数，作为群体祖先构成的估计值。比较了先证者和对照组中HLA - DRB104等位基因频率及其与祖先国家的关系。将结果与具有HLA - DRB104频率的欧洲人群的结果进行比较。
90名可评估的成年白人皮肤黑色素瘤先证者和324名成年白人对照者报告了其祖父母的祖先所在国家。先证者中报告爱尔兰、苏格兰和“不列颠群岛”为祖先所在国家的频率显著高于对照组。威尔士、法国、意大利和波兰在对照组中的频率显著更高。16.7%的黑色素瘤先证者和23.8%的对照者报告有“美洲原住民”血统；先证者和对照组中相应的“美洲原住民”祖先国家指数没有显著差异。先证者中HLA - DRB104的频率显著更高，但与个体或综合祖先国家没有显著关联。将在阿拉巴马州观察到的DRB104频率与英格兰、威尔士、爱尔兰、奥克尼岛、法国、德国和澳大利亚报告的DRB1*04频率进行了比较。
阿拉巴马州中部患有皮肤黑色素瘤的成年白人以爱尔兰、苏格兰和“不列颠群岛”血统为主，且HLA - DRB1*04可能导致了他们皮肤黑色素瘤的高发病率。
