Edwards Mandy L, Fagan Peter K, Towers Rebecca J, Currie Bart J, Sriprakash Kadaba S
Menzies School of Health Research, Darwin, Australia.
Microbes Infect. 2004 Aug;6(10):926-8. doi: 10.1016/j.micinf.2004.05.006.
Streptococcus pyogenes (group A streptococcus, GAS) is a human-specific pathogen, which employs a large number of adhesins for colonization. Fibronectin-binding proteins (FBPs) play a major role in GAS adhesion to host cells. SfbI, a major streptococcal FBP, has been well studied. A peptide (peptide-MSG) based on this adhesin inhibits fibronectin (Fn)-binding by the pathogen. To test whether this peptide also inhibits adherence of GAS to host cells, adhesion assays were performed with strains possessing different combinations of genes for three distinct FBPs. Peptide-MSG inhibited GAS adherence to human keratinocytes (HaCaT) in a strain dependent manner. There is no consistent pattern between the effect and the ability to express one or more of the FBPs. A single peptide may be insufficient to prevent GAS adherence to host cells.
化脓性链球菌（A 组链球菌，GAS）是一种人类特异性病原体，它利用大量黏附素来进行定植。纤连蛋白结合蛋白（FBPs）在 GAS 黏附宿主细胞过程中起主要作用。SfbI 作为主要的链球菌 FBP，已得到充分研究。基于这种黏附素的一种肽（肽 - MSG）可抑制病原体与纤连蛋白（Fn）的结合。为了测试这种肽是否也能抑制 GAS 对宿主细胞的黏附，我们对具有三种不同 FBPs 基因不同组合的菌株进行了黏附试验。肽 - MSG 以菌株依赖性方式抑制 GAS 对人角质形成细胞（HaCaT）的黏附。在这种效应与表达一种或多种 FBPs 的能力之间没有一致的模式。单一肽可能不足以阻止 GAS 对宿主细胞的黏附。
