Hickman Matthew, Higgins Vanessa, Hope Vivian, Bellis Mark, Tilling Kate, Walker Angeline, Henry John
CRDHB, Social Science and Medicine, Imperial College, Charing Cross Campus, St Dunstans Road, London SW6 1RQ, UK.
J Epidemiol Community Health. 2004 Sep;58(9):766-71. doi: 10.1136/jech.2003.015164.
To estimate the prevalence of injecting drug use (IDU) in three cities in England and to measure the coverage of key public health indicators.
Capture-recapture techniques with covariate effects.
Liverpool, Brighton, and 12 London boroughs, 2000/01.
IDU collated and matched across five data sources-community recruited survey, specialist drug treatment, arrest referral, syringe exchange, and accident and emergency-896 in Brighton, 1224 in Liverpool, and 6111 in London.
It is estimated that in 2000/01 the number and prevalence of IDU aged 15-44 was 2300 (95%CI 1500 to 3700) and 2.0% (95%CI% 1.3% to 3.2%) in Brighton; 2900 (95%CI 2500 to 5000) and 1.5% (95%CI 1.3% to 2.6%) in Liverpool; 16 700 (95%CI 13 800 to 21 600) and 1.2% (95%CI 1.0% to 1.6%) in 12 London boroughs; with a prevalence of 1.7% (95%CI 1.2% to 3.3%) in inner London. It is estimated that: less than one in four IDU are in treatment in the three areas; syringe exchange programmes covered about 25% of injections in Brighton and Liverpool and 20% in London; and that the annual opioid mortality rate among IDU was 2% in Brighton compared with less than 1% in Liverpool and London.
Credible estimates of the prevalence of injecting drug use (and key public health indicators) can be determined using covariate capture-recapture techniques. These suggest that: targets to double the number in treatment are possible: syringe distribution should be increased; and further attention, especially in Brighton, given to reducing overdose mortality.
评估英格兰三个城市注射吸毒(IDU)的流行情况,并衡量关键公共卫生指标的覆盖范围。
采用带有协变量效应的捕获再捕获技术。
利物浦、布莱顿以及伦敦的12个行政区,时间为2000/01年。
通过五个数据源整理并匹配注射吸毒者——社区招募调查、专业戒毒治疗、逮捕转介、注射器交换以及事故与急诊——布莱顿有896人,利物浦有1224人,伦敦有6111人。
据估计,在2000/01年,布莱顿15至44岁注射吸毒者的数量和流行率分别为2300人(95%置信区间为1500至3700)和2.0%(95%置信区间为1.3%至3.2%);利物浦为2900人(95%置信区间为2,500至5000)和1.5%(95%置信区间为1.3%至2.6%);伦敦12个行政区为16700人(95%置信区间为13800至21600)和1.2%(95%置信区间为1.0%至1.6%);伦敦市中心为1.7%(95%置信区间为1.2%至3.3%)。据估计:在这三个地区,接受治疗的注射吸毒者不到四分之一;注射器交换项目覆盖了布莱顿和利物浦约25%的注射吸毒者,在伦敦为20%;布莱顿注射吸毒者的年度阿片类药物死亡率为2%,而利物浦和伦敦则不到1%。
使用协变量捕获再捕获技术可以得出注射吸毒(以及关键公共卫生指标)流行率的可靠估计值。这些结果表明:有可能实现将接受治疗人数翻倍的目标;应增加注射器的分发;尤其在布莱顿,应进一步关注降低过量用药死亡率。