Hope Vivian D, Hickman Matthew, Tilling Kate
Centre for Research on Drugs and Health Behaviour, Imperial College London, London, UK.
Addiction. 2005 Nov;100(11):1701-8. doi: 10.1111/j.1360-0443.2005.01244.x.
To estimate the prevalence of crack cocaine use in 12 London Boroughs (and London as a whole).
Twelve London Boroughs, 2000-01.
(1) Covariate capture-recapture techniques applied to three data sources of subjects reporting crack cocaine use: specialist drug treatment (2905), arrest referral (1188) and accident and emergency and community survey (531); and (2) ratio-estimation multiplier, using an estimate of number of injecting drug users and proportion that use crack cocaine.
After matching, 4117 individuals aged 15-44 were identified. The best-fitting model estimated 16 855 unobserved crack cocaine users, giving an overall estimate of approximately 21 000 [95% confidence interval (CI) 13 000-43,000] and a prevalence of 1.5% (95% CI 1.0-3.2%). Prevalence of crack cocaine use was 2.4% (95% CI 1.5-5.0%) among men and 0.7% (95% CI 0.5-1.0%) among women, and similar by age groups 15-29 and 30-44 years. Overall, approximately 11 900 (57%) of the estimated number of crack cocaine users were also opiate users. In London as a whole there may be 46,000 (1.3%) crack cocaine users aged 15-44 years, with 28 000 (1.9%) in inner London-four times higher than estimates from population surveys. Some corroboration was provided by the ratio-estimation method, which estimated 23 000 users in the 12 Boroughs.
Capture-recapture can be applied to crack cocaine and obtain better estimates than population surveys. The size of the crack cocaine-using population in London is large, although currently the majority are also opiate users. Given that half of current users are under 30 the problems associated with crack cocaine use are likely to increase in the future.
评估伦敦12个行政区(及整个伦敦)中使用快克可卡因的流行情况。
2000 - 2001年,伦敦12个行政区。
(1) 将协变量捕获 - 再捕获技术应用于报告使用快克可卡因的受试者的三个数据源:专业药物治疗(2905人)、逮捕转介(1188人)以及事故与急救及社区调查(531人);(2) 比率估计乘数法,使用注射吸毒者数量估计值及使用快克可卡因的比例。
匹配后,识别出4117名年龄在15 - 44岁的个体。拟合度最佳的模型估计有16855名未被观察到的快克可卡因使用者,总体估计约为21000人[95%置信区间(CI)13000 - 43000],流行率为1.5%(95%CI 1.0 - 3.2%)。男性中快克可卡因的使用率为2.4%(95%CI 1.5 - 5.0%),女性为0.7%(95%CI 0.5 - 1.0%),15 - 29岁和30 - 44岁年龄组相似。总体而言,估计的快克可卡因使用者中约11900人(57%)也是阿片类药物使用者。在整个伦敦,15 - 44岁的快克可卡因使用者可能有46000人(1.3%),其中伦敦市中心有28000人(1.9%),是人口调查估计值的四倍。比率估计法提供了一些佐证,该方法估计12个行政区有23000名使用者。
捕获 - 再捕获方法可应用于快克可卡因,且能获得比人口调查更好的估计值。伦敦使用快克可卡因的人群规模较大,尽管目前大多数也是阿片类药物使用者。鉴于目前一半的使用者年龄在30岁以下,未来与使用快克可卡因相关的问题可能会增加。