Hemraj Farah, Garces Kirsten
Issues Emerg Health Technol. 2004 Aug(59):1-4.
Insulin glargine is a biosynthetic human insulin analogue that controls blood glucose levels over 24 hours without a pronounced peak. In most studies in patients with type 2 diabetes mellitus (DM), insulin glargine did not significantly reduce fasting blood glucose, fasting plasma glucose or hemoglobin A1c compared to NPH insulin. Most trials showed a statistically significant decrease in the incidence of nocturnal and symptomatic hypoglycemia. This may not be as much of a concern in most patients with type 2 DM compared to type 1 DM. Current evidence suggests that patients who are adequately controlled with NPH insulin will not gain additional benefit from insulin glargine.
甘精胰岛素是一种生物合成的人胰岛素类似物，可在24小时内控制血糖水平，且无明显峰值。在大多数针对2型糖尿病（DM）患者的研究中，与中性鱼精蛋白锌胰岛素相比，甘精胰岛素在降低空腹血糖、空腹血浆葡萄糖或糖化血红蛋白方面并无显著效果。大多数试验显示，夜间和症状性低血糖的发生率有统计学意义的下降。与1型糖尿病患者相比，这在大多数2型糖尿病患者中可能不那么令人担忧。目前的证据表明，使用中性鱼精蛋白锌胰岛素得到充分控制的患者不会从甘精胰岛素中获得额外益处。
