Shi Bing-bing, Zhang Xiang-hong, Wang Hui-jun, Li Han-zhong
Department of Urology, Peking Union Medical College, Beijing 100730, China.
Zhonghua Zhong Liu Za Zhi. 2004 Jun;26(6):356-8.
To study the clinical significance of expression of hepatic growth factor (HGF) and its receptor c-Met in renal cell cancer (RCC).
Twenty-six patients with RCC and 10 benign renal tumor patients were examined. The expression of HGF and c-Met mRNA was detected using Northern blot. GAPDH was used as the internal control.
Twenty-one out of 26 patients with RCC had positive gene expression of HGF and c-Met with the positive rate of 80.8%. According to the tumor TNM staging, the more advanced the cancer had a stronger expression of HGF and c-Met, the expression of c-Met was higher than that of HGF in the RCC. Whereas in the control group with benign tumor, the expression of c-Met was rather mild.
The result suggests that HGF and its receptor c-Met may play an important role in the development and progression of renal cancer, which may also imply a potential clinical significance in diagnosing and assessing prognosis of RCC.
研究肝细胞生长因子（HGF）及其受体c-Met在肾细胞癌（RCC）中的表达及其临床意义。
检测26例肾细胞癌患者及10例肾良性肿瘤患者。采用Northern印迹法检测HGF和c-Met mRNA的表达。以甘油醛-3-磷酸脱氢酶（GAPDH）作为内对照。
26例肾细胞癌患者中21例HGF和c-Met基因表达阳性，阳性率为80.8%。根据肿瘤TNM分期，癌症越晚期，HGF和c-Met表达越强，肾细胞癌中c-Met的表达高于HGF。而在良性肿瘤对照组中，c-Met的表达较为轻微。
结果提示HGF及其受体c-Met可能在肾癌的发生发展中起重要作用，这对肾癌的诊断和预后评估可能具有潜在的临床意义。
