Pepicelli Olimpia, Raiteri Maurizio, Fedele Ernesto
Dipartimento di Medicina Sperimentale, Sezione di Farmacologia e Tossicologia, Università di Genova, Genova, Italy.
Neurochem Int. 2004 Nov;45(6):787-97. doi: 10.1016/j.neuint.2004.03.009.
It is now well established that nitric oxide is involved in a variety of physiopathological processes in the central nervous system, which mainly result from the interaction of this gaseous molecule with the heme group of soluble guanylyl cyclase and the elevation of intracellular cGMP in target neurons. During the last decade, several studies have monitored extracellular cGMP, by means of intracerebral microdialysis, to investigate in vivo the functioning and modulation of this neurochemical pathway under different experimental conditions and in various brain regions. In this review, we summarise some of the most relevant results obtained in this research field.
现已充分证实，一氧化氮参与中枢神经系统的多种生理病理过程，这些过程主要源于这种气态分子与可溶性鸟苷酸环化酶的血红素基团相互作用以及靶神经元内细胞内cGMP升高。在过去十年中，多项研究通过脑内微透析监测细胞外cGMP，以在体内研究该神经化学途径在不同实验条件下及不同脑区的功能和调节。在本综述中，我们总结了该研究领域获得的一些最相关结果。
